• CAplus -
  >29 million documents
• MEDLINE -
  >17 million references

• >37 million organic and inorganic substances
• >60 million sequences (view latest numbers)

• >15 million single- and multi-step reactions

• >246,000 inventoried or regulated chemicals

• >23 million commercially available chemicals

CAplus - Journal articles and patent documents chemistry and related sciences

• proteomics
• genomics
• biochemistry
• biochemical genetics
• organic
• macromolecular
• applied
• physical, inorganic, analytical

MEDLINE - Produced by NLM, and covers all areas in the broad field of biomedicine

Information about the many different types of substances, including:

• synonyms
• molecular formulas
• nucleic acid and protein sequences
• ring analysis data
• structure diagrams
• experimental and calculated property data

Reaction information consisting of:

• structure diagrams for reactants and products
• CAS Registry Numbers for all reactants products, reagents, solvents, and catalysts
• yields for many products
• textual reaction information

Chemical substances that are regulated in key markets across the globe:

• chemical names
• synonyms
• regulatory lists
• chemical inventory status

Information about commercially available chemicals and their worldwide suppliers:

• CAS Registry Number 
• supplier information

CAplus

• 1907 to present, plus more than 44,000 pre-1907 journal records and more than 1,250 records for U.S. patents issued from 1808-1859 
• more than 10,000 scientific journals
• patents from 57 patent authorities
• conference proceedings
• technical reports
• books
• dissertations
• reviews
• meeting abstracts
• electronic-only journals
• web preprints

MEDLINE

• 1949 to present
• 4,800 biomedical journals
• 99% of references are from journal literature
• 1949-1965 from OLDMEDLINE database

• Complete coverage from 1957 to present
• Many substances back to the early 1900s
• New substances as identified by the CAS Registry System
• GenBank sequences
• Organic and inorganic substances including:
  - alloys
  - coordination compounds
  - minerals
  - mixtures
  - polymers
  - salts
  - sequences

• 1840 to present
• Journals covered for Chemical Abstracts^TM since 1985
• Patents covered for CA from 1991 to present

• Originally from data in the 1985 TSCA inventory and supplements
• U.S. Government Federal Register 1778-1987
• 13 national inventories
• State lists

• >900 suppliers of commercial chemicals worldwide
• >1000 chemical catalogs

CAplus - 3,000 references daily

MEDLINE - 4 times per week