Comprehensive insights on lipid-based drug delivery systems

Report summary

Lipid-Based Drug Delivery Systems: Unlock the Future of Drug Delivery examines historic advancements, the current landscape, and the future of lipid-based drug delivery. Leveraging over 200,000 indexed scientific documents from the CAS Content Collection™, our scientists provide actionable insights to help guide the future development of these systems, ensuring your next project has a solid foundation.

Pharmaceutical decision-makers, investors, R&D leaders, and strategists seeking data-driven insights into lipid-based drug delivery innovations will benefit from the insights in this comprehensive report. This data-driven intelligence will help you maintain an edge in the rapidly evolving field of drug delivery.

Fanned display of the lipid report

What is the function of lipids?

Lipids, essential components of biological membranes, possess numerous unique functions that make them viable candidates in many scientific and pharmacological fields. Lipid-based drug delivery is revolutionizing the pharmaceutical industry, with ongoing discoveries about their unique properties driving drug discovery innovations.

The high biocompatibility and versatility of lipids can help overcome common challenges in pharmacological delivery methods, such as poor solubility, low availability, rapid degradation, and off-target effects. Additionally, they encapsulate many compounds, including small-molecule drugs, nucleic acids, and peptides, thereby expanding their therapeutic range.

Lipid nanoparticles and other lipid-based drug delivery systems

From early platforms like simple liposomes to advanced systems such as solid lipid nanoparticles and stimuli-responsive smart lipid systems, the field has experienced remarkable innovation and growth. Engineered lipids—including ionizable, PEGylated, branched-chain, polymerizable, and bioresponsive variants—enable precise and efficient delivery of small molecules, genetic material, and biologics. These advancements reshape treatment paradigms in oncology, infectious diseases, gene therapy, and other diseases, solidifying lipids as a cornerstone of cutting-edge therapeutics.

In Lipid-Based Drug Delivery Systems, we examine a wide range of lipid-based delivery systems. By combining the latest advancements in lipid nanotechnology with insights from preclinical and clinical studies, this report provides a roadmap for the rational design and optimization of lipid nanoparticles and other lipid-based carriers for diverse therapeutic interventions.

The future these delivery systems is promising, driven by advancements in nanotechnology and personalized medicine. These innovations will continue improving the effectiveness, safety, and patient acceptability of therapies while addressing global health challenges and environmental sustainability.

What you will learn about the future of drug delivery

  • The unique roles and mechanisms of different lipids used in drug delivery
  • The latest data trends and innovation pipelines in lipidic drug carriers
  • How lipids are driving advancements in delivery applications
  • Leading organizations actively researching lipid-based drug delivery
  • Novel approaches to customizing lipids for therapeutic innovations
  • Challenges and opportunities lipids pose for the future of drug delivery

Whether you are in R&D, strategy, or investment, Lipid-Based Drug Delivery Systems equips you with the knowledge to innovate and excel in this dynamic field.

Table of contents

The Global R&D Landscape for Lipid-Based Drug Delivery Technologies – CAS TrendScape™ Map

Cutting-Edge Research and Publication Trends

Leading Innovators: Top Academic Organizations and Commercial Companies

Recent Breakthroughs Influencing Future Directions

Current Trends in Major Lipid Classes

Lipid Innovations Shaping the Future of Drug Delivery

  • Cationic Lipids – The Silver Bullet in Nonviral Gene Delivery
  • Ionizable Cationic Lipids – The Rising Star in Drug Delivery
  • PEGylated Lipids – Making Drug Delivery Systems Invisible
  • Targeting Ligands for Precision Medicine
  • Stimuli-Responsive Lipids – Smart Delivery Systems
  • Cross-linkable/Polymerizable Lipids – Enhanced Stability
  • Lipids as Imaging Agents for Real-Time Monitoring
  • Theranostic Lipids – Combined Diagnostics and Therapy
  • Lipid-Drug Conjugates (Lipidic Prodrugs): Better Pharmacokinetics, Lower Toxicity

Polar Lipids – Back to Basics

Neutral Lipids

Lipid Stereochemistry

Natural Lipid Extracts

Synthetic Biology: Lipid Synthesis Revolution

Chemical Synthesis Pathways

  • Ionizable Lipids
  • Cationic Lipids
  • PEG Lipids

Leading Companies in Lipid Synthesis and Methodologies

Lipid Molecular Shape

Lipid Phase Transition Temperatures

Lipid Polymorphism and Mesomorphism in Drug Delivery Systems

Impact of Lipid Phase Transitions in Drug Delivery

  • Solid – Liquid Crystalline (Melting) Transition
  • Lamellar – Nonlamellar Transition

Liposomes – The Pioneers of Lipid DDS  

Lipid Nanoparticles (LNPs) – Breaking Boundaries

  • Solid Lipid Nanoparticles and Nanostructured Lipid Carriers – Aiming for Perfection
  • Cationic/Ionizable Lipid Nanoparticles and Lipoplexes: The Nucleic Acid Vectors

Micelles: Small Size and Enhanced Permeability

Advanced Emulsion Systems: Microemulsions and Nanoemulsions

Ethosomes: Efficient Skin Penetration

Exosomes: Nature-Inspired Drug Carrier

Virus-Like Particles (Enveloped)

Hybrid Lipid Nanoparticles: Combining Strengths

Others

Key Trends of Lipid-Based Drug Delivery Systems

Formulation Techniques

Characterization Techniques

Conventional Routes of Administration for Lipid DDS

Innovative Delivery Routes for Lipid DDS

Cancer

Infectious Diseases

Nervous System Disorders

Metabolic Disorders

Cardiovascular diseases

Clinical Trials

Regulatory Approved Drugs Utilizing Lipid-Based DDS

Advantages of Lipid-Based Drug Delivery Systems

Overcoming Challenges in Lipid-Based Drug Delivery

Future Directions

Methodology

The CAS Content Collection, the world’s largest human-curated scientific database, forms the data foundation of Lipid-Based Drug Delivery Systems: Unlock the Future of Drug Delivery, ensuring unparalleled accuracy, depth, and reliability. Our leading lipid chemistry and drug delivery experts have collaborated with data scientists and business leaders to generate insights that surpass conventional literature reviews using advanced analytical capabilities and state-of-the-art data tools.

Drawing from 200,000 carefully curated journal articles and patents from 2003 to 2024, this report delivers a unique competitive edge by quantifying critical elements of lipid-based drug delivery. We transform complex data into actionable intelligence by classifying key scientific terms, counting patents by patent families, tracking chemical substances, and mapping synthesis reactions.

Search strategy

CAS subject-matter experts meticulously crafted and iteratively refined our search query to minimize irrelevant data while ensuring a holistic capture of all significant developments.

Data extraction

With exclusive access to high-quality scientific data in the CAS Content Collection, we extracted and structured data across multiple dimensions.

  • Journal publications (2003 - 2024)
    • Title, abstract, publication year, citation impact
    • Authors and affiliated research institutions
  • Patent families (2003 - 2024)
    • Patent offices, assignees, and families
  • CAS-indexed scientific concepts and chemical substances' contextual roles in publications
  • CAS-indexed substance names, CAS Registry Numbers, chemical structures, synthetic pathways, and chemical reactions
  • Chemical supplier information

Data analysis

  • Patent intelligence and competitive landscape
    • Identifying leading patent assignees based on patent family volume
    • Distinguishing between commercial and noncommercial entities
  • Research and publishing trends
    • Pinpointing top journal publishers and research institutions using a combination of publication volume and citation impact
  • Geographical insights and market expansion potential
    • Mapping global research activity by analyzing the country/region and organizational affiliations
    • Identifying strategic collaborations among organizations by analyzing patent co-filing activities
  • Keyword and concept mining
    • Searching across titles, abstracts, and CAS-indexed scientific concepts and substances
    • Incorporating synonyms and abbreviations for comprehensiveness

Why CAS?

CAS, a division of the American Chemical Society, is a world-leading scientific information solutions organization focused on transforming lives through the power of science. We curate, collect, and analyze published scientific literature to create solutions, including CAS SciFinder®.

By staying up to dates with published literature, scientific advancements, and the happenings of each related industry, we bring together unique expert insights unavailable anywhere else.

Contact us

For questions related to Lipid-Based Drug Delivery Systems: Unlock the Future of Drug Delivery, please reach out to the CAS Customer Center.

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  • Instant access via PDF
  • More than 100 custom-designed figures, tables, and synthetic schemes
  • Over 1,200 published references and hundreds of unique substances with CAS Registry Numbers®
  • Analysis of active commercial and academic research trends
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