PEGylation is a breakthrough technique to improve drug delivery systems, but it also has a downside: it can trigger immune reactions that reduce drug efficacy and safety. Designed for R&D leaders, this idea in brief shows how we can overcome this challenge. It summarizes the latest trends and opportunities, PEG-lipid structure, LNP composition and properties, and which pharmaceutical parameters affect their immunogenicity and efficiency. Learn more and share with your network: