Despite being a well-established discipline, synthetic organic chemistry has continued to advance in the last decade with the goal of meeting society's needs in all parts of life. It is important to understand the history of organic synthesis because of its significance for chemistry, technology, and even humanity.

In collaboration with National Natural Science Foundation of China and National Science Library at the Chinese Academy of Sciences, this detailed landscape of synthetic organic chemistry reveals hidden connections and new opportunities from within the CAS Content Collection. From publication trend analysis and subject matter experts' reviews, three important rising organic synthesis research areas were chosen: enzyme catalysis, photocatalysis, and green chemistry. This report will help researchers and decision-makers understand the current state of the worldwide research effort in this area and help them foresee potential prospects and applications for organic synthesis in the future.