In collaboration with National Natural Science Foundation of China and National Science Library at the Chinese Academy of Sciences, this detailed landscape of synthetic organic chemistry was published jointly in Organic Letters and the Journal of Organic Chemistry. This publication reviews hidden connections and new opportunities from within the CAS Content Collection. Three important research areas were chosen: enzyme catalysis, photocatalysis, and green chemistry. This will help researchers and decision-makers understand the current state of the worldwide research effort in this area and help them foresee potential prospects and applications for organic synthesis in the future.