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Enfermedades raras y enfermedades huérfanas: ¿pueden tratarse las terapias combinadas?
Cómo las terapias combinadas, como la reutilización de fármacos, la terapia celular y la terapia génica, están mejorando el tratamiento de las enfermedades raras.
Are inverse vaccines the cure for autoimmune diseases?
Sharing new research on inverse vaccines, potential new breakthroughs in treating autoimmune diseases like multiple sclerosis, type 1 diabetes and celiac disease
Ending Alzheimer's: Emerging trends in biomarkers, gene therapy, and more
Biomarkers, personalized medicine and gene therapies are fueling research breakthroughs. Discover new treatments targeting genetics and protein buildup to manage this devastating disease.
Types of antisense oligonucleotides: Advancing therapeutic frontiers
Different types of antisense oligonucleotide therapies, such as exosomes and nanoparticles, offering new hope in genetic medicine.
Can we cure Huntington's? Research trends in PolyQ and rare diseases
While no cure exists for PolyQ diseases like Huntington's, new breakthroughs, therapies, and research could change that.
Challenges and opportunities in discovering novel drugs for “undruggable” targets
We speak with Mauro Mileni, Ph.D., and Chris Roth, Ph.D., about how their company is leveraging specific technology to fill an innovative drug pipeline.
R&D Insight: Unique views into immuno-oncology
Immunotherapy is advancing with new approaches like CAR-T cell therapy, antibody-drug conjugates, and even checkpoint inhibitors.
Emerging trends in immunotherapy and cancer
Immuno-oncology has the potential to treat cancer without sacrificing the patient's wellbeing.
Dealing with the challenges of drug discovery
The pharma industry is tackling major drug discovery challenges in several new ways. Have they been successful?
Challenges and opportunities in creating authority constructs for life sciences
In this article, we speak with Nicole Stobart, Jeff Wilson, and Mark Schmidt, about how CAS is using authority constructs to index biological molecules.
Challenges and opportunities in protein function prediction for drug discovery
Iddo Friedberg, an expert in protein function prediction, shares how current prediction models are performing and what current bottlenecks remain.
R&D insights: The covalent inhibitor revolution
Covalent inhibitors were once avoided due to negative side effects, but new drugs have changed the landscape.
R&D insights: Antibody-drug conjugates
More than 100 antibody-drug conjugates are in clinical trials. These therapeutics combine the targeting abilities of antibodies with the power of chemotherapy to change cancer treatment.
Unveiling the potential of the antibody drug conjugate
Since 2018, research interest in antibody-drug conjugates has increased exponentially, due to their potential in the fight against cancer.
Challenges and opportunities in sequence analysis during drug discovery
We talk with Jefferson Parker of NullSet Informatics Solutions, about sequence analysis for drug discovery and the frontiers for AI in computational biology.
Targeted protein degradation and induced proximity: Molecular glues landscape in drug discovery
Induced-proximity target protein degradation (TPD) is a ground-breaking strategy in drug discovery that has emerged recently.
Challenges and opportunities in structure-activity-relationship (SAR) studies
We chat with Ben Taft, Sr. Director of Chemistry at Via Nova Therapeutics, about SAR studies and the possible frontiers for bioactivity data.
ACE2: Targeting a potentially important receptor in disease pathogenesis
The ACE2 protein is the critical target for COVID-19 and other viral infections, and this knowledge has led to new therapeutics.
Exosome research: from platelet dust to pioneering therapeutics
Landscape view of emerging contributors, companies, and researchers in the emerging field of exosome research. This article overviews key players in diagnostics and therapeutic fields of exosome research with a deeper look into the current clinical pipeline.
Expedited FDA designation of breakthrough therapy
The FDA can designate drug candidates as “breakthrough therapies” (breakthrough therapy designation or BTD) for certain drug candidates that demonstrate substantial improvement over available therapies on a clinically significant endpoint.
Exosome therapy and diagnostics: the path to becoming clinical giants
Exosomes could revolutionize drug delivery and diagnostics, but face isolation and purification challenges. This article explores recent trends in exosome research, focusing on their applications in drug delivery, diagnostics, and therapeutics. Discover how these unique particles are shaping the fut
Bioorthogonal chemistry and its applications
Bioorthogonal chemistry is a set of methods that use the chemistry of non-native functional groups to analyze biology in living organisms.
The therapeutic potential of nanotechnology beyond COVID-19
Explore lipid nanoparticles: from origins to COVID vaccines and beyond. Discover emerging trends in publications and milestones. Uncover future applications in vaccines, drug delivery, and non-therapeutic fields like agro-chemistry, cosmetics, and food science. Learn how these particles are shaping
Cytokine storm warning: The critical role of cytokines in immunity and infection
Learn more about cytokine storms and their role in both immunity and severe infection with COVID-19 and additional viral infections. This overviews emerging trends and insights on publications, milestones, and future applications to minimize the impact of cytokine adverse effects.
ACS webinar on molecular glues and targeted protein degradation
Expert panelists include Dr. Benjamin Ebert, the chair of Medical Oncology at the Dana-Farber Institute, Dr. Phil Chamberlain, the co-founder, President, and CEO of Neomorph, and Janet Sasso, an information scientist specializing in Life Sciences at CAS.
How mRNA COVID-19 vaccines work to fight COVID-19
When mRNA (messenger RNA) vaccines are injected into a patient, tiny lipid vesicles transport mRNA molecules through the body fluids and merge with immune cells, called antigen-presenting cells (APCs).
Targeting ACE2 for treatments of COVID-19
Scientists are searching ways to stop the spread of COVID-19, and the ACE2 receptor is one of the most promising targets.
AI drug discovery: assessing the first AI-designed drug candidates to go into human clinical trials
This blog details the recently published CAS indicator of drug innovation based on the structural novelty of new molecular entities (NMEs) which may better assess innovativeness of new drugs.
Breakthrough therapy designation: The real-world impact of structural novelty
Find out how companies improve their prediction accuracy, obtain Breakthrough Technology Status and shorten the development and review time of new drugs by leveraging CAS advanced machine learning methods.
Bioorthogonal chemistry: A review of its diverse applications in science and medicine
Bioorthogonal chemistry is a set of methods using the chemistry of non-native functional groups to explore and understand biology in living organisms.
Accelerating discovery: COVID-19 vaccine breakthroughs and their future impact
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
Accelerating Discovery: COVID-19 Vaccine Breakthroughs and their Future Impact
This insight report explores innovative research and technologies that played crucial roles in Covid-19 vaccine development.
Emerging trends in targeting "undruggable" RAS proteins for cancer treatment
It is estimated that one in five human cancers involve RAS mutations. Although once considered undruggable, this blog looks at recent advances in RAS inhibitors and emerging therapies.
With COVID BA.5 and BA.2.75 variants, are masks back in?
The COVID pandemic revealed deficiencies in mask development and production. Innovation will be crucial in slowing the spread of new variants of the virus.
How molecular glues are connecting targeted protein degradation to the clinic
Targeted protein degradation is a novel and quickly expanding drug discovery strategy. It is a new way of utilizing disease-causing proteins to attack severe illnesses, which has the potential to be used among more serious illnesses, such as cancer or neurodegenerative diseases.
Why the omicron BA.5 variant evades vaccines
As COVID-19 cases rise again worldwide, the Omicron subvariant BA.5 is currently the dominant strain. This blog explores some key mutations that increase transmission, evade protective antibodies, and increase the rate of (re)infection.
The Landscape of Artificial Intelligence in Chemistry and Opportunities for Growth
Artificial intelligence (AI) and machine learning have been growing exponentially over the last decade, but how has the field of Chemistry evolved with this emerging trend?
Lipid Nanoparticles: Past, Present, and Future Opportunities
Lipid nanoparticles play critical roles in mRNA vaccines for treating COVID-19, but their use is not new. Read about past, present, and future opportunities.
RNA-Derived Medicines: A review of the research trends and developments
The use of RNA in therapeutics has the potential to revolutionize medicine. This white paper highlights the emerging trends in the industry.
The progress and promise of RNA medicine─An arsenal of targeted treatments
The last decade has seen a dramatic shift towards RNA-based medicine. Rapid success in developing lipid-RNA nanoparticles for COVID-19 mRNA vaccines, along with several approved drugs, has propelled RNA to the forefront of pharmaceutical research and development. Explore this revolutionary trend.
Knowledge graphs accelerate COVID-19 therapies
This white paper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.
Are intrinsically disordered proteins the key to treating COVID-19?
Learn about the important functions of intrinsically disordered proteins and the key role they play in COVID-19 therapy.
COVID vaccine ingredients for children under 5
This blog lists and discusses the common ingredients (both in the household and scientific contexts) as well as the unique ingredients used in the Covid-19 vaccines currently in use in the United States, and also addresses the dosage levels proposed for children under five years of age.
Omicron variant accelerates need for more diverse COVID-19 vaccine strategy
Omicron's significant evolution from the original COVID-19 virus raises concerns about reinfection and vaccine evasion. This variant could potentially bypass existing immunity, threatening global pandemic recovery efforts. Explore the potential societal and economic impacts of this new challenge.
Exploring knowledge graphs for COVID-19 drug discovery
The methodology behind CAS knowledge graphs enhances potential drug identification for COVID-19 treatment and other diseases.
Knowledge graph-based approaches to drug repurposing for COVID-19
The COVID-19 pandemic has motivated researchers across the globe to find effective drugs and therapeutics for treating the disease.
Inteligencia artificial en química: tendencias actuales y direcciones futuras
En los últimos años, la aplicación de la IA a la química ha crecido rápidamente. Si bien ha habido mucha publicidad sobre la IA utilizada de esta manera, no ha habido muchos análisis en profundidad sobre su uso y desarrollo en el campo de la química.
The research landscape and advancement of lipid nanoparticles
Lipid nanoparticles (LNPs) have emerged as promising vehicles to deliver a variety of therapeutics in the pharmaceutical industry. Liposomal drugs, based on an earlier version of LNPs, have already been approved and applied to medical practice.
A review of the global efforts on COVID-19 vaccine development
This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.
Building A Foundation For Profitable Digital Transformation in Sci-Tech R&D
Artificial Intelligence may be hot right now, but the smart money is investing in data. See how CAS solutions can help.
QSAR machine learning models and their applications for identifying potential COVID-19 therapeutics
To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).
Seeking COVID-19 therapeutic candidates with a computational approach
Learn how machine learning procedures and CAS COVID-19 resources, including scientific insights, open access datasets and special reports are assisting in the research to fight against COVID-19.
Taking aim at COVID-19’s most wanted targets
In support of ongoing research efforts to identify additional drugs for COVID-19, a team of CAS scientists analyzed published scientific information and created a comprehensive report focusing on proteins involved in COVID-19 and potential corresponding drug candidates.
Potential therapeutic agents and associated bioassay data for COVID-19 and related human coronavirus infections
This report aids COVID-19 therapeutic research by summarizing protein targets and potential drug candidates. It includes bioassay and structure-activity relationship data from scientific and patent literature for COVID-19 and related viral infections. Explore key insights to support ongoing drug dev
The enemy within: How SARS-CoV-2 uses our own proteins to infect our cells
A critical step in the race to develop treatments for COVID-19 is to gain a clear understanding of how the virus enters our cells. This insight will support development of targeted antiviral treatments focused on blocking that pathway.
Assay techniques and test development for COVID-19 diagnosis
To provide a better understanding and comparison of the diagnostic tests available in the fight against COVID-19, CAS has produced a report summarizing the basic principles of molecular and serological assays being used in diagnostic tests for SARS-CoV-2.
Research and development on therapeutic agents and vaccines for COVID-19 and related human coronavirus diseases
To support R&D on COVID-19, CAS has produced a special report to provide an overview of published scientific information with an emphasis on patents in the CAS content collection.
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