CAS Insights^TM

The COVID-19 pandemic has motivated researchers across the globe to find effective drugs and therapeutics for treating the disease.

Learn more about what performance-enhancing drugs are, how they are detected, and the future development of non-targeted detection methods.

In recent years, AI application to chemistry has rapidly grown. While there has been numerous publicity about AI used in this manner, there hasn’t been a lot of in-depth analysis on its use and development in the chemistry field.

Lipid nanoparticles (LNPs) have emerged as promising vehicles to deliver a variety of therapeutics in the pharmaceutical industry. Liposomal drugs, based on an earlier version of LNPs, have already been approved and applied to medical practice.

This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.

The Pistoia Alliance Chemical Safety Library (CSL) is an open-access database providing access to hazardous reaction information crowd-sourced from academic, industry, and government institutions around the world. Developed and hosted by CAS, the CSL supports laboratory safety.

An overview of research on how microbial enzymes can break down plastics, which could otherwise take hundreds of years to degrade.

This in-depth CAS Insights Report discusses the chemical properties of ammonium nitrate, its hazards and safety rules, and provides a useful resource for those involved in the handling and storage of this compound.

Artificial Intelligence may be hot right now, but the smart money is investing in data. See how CAS solutions can help.

To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).

Learn how machine learning procedures and CAS COVID-19 resources, including scientific insights, open access datasets and special reports are assisting in the research to fight against COVID-19.

In support of ongoing research efforts to identify additional drugs for COVID-19, a team of CAS scientists analyzed published scientific information and created a comprehensive report focusing on proteins involved in COVID-19 and potential corresponding drug candidates.

This report aids COVID-19 therapeutic research by summarizing protein targets and potential drug candidates. It includes bioassay and structure-activity relationship data from scientific and patent literature for COVID-19 and related viral infections. Explore key insights to support ongoing drug dev

In this article from The Patent Lawyer Magazine, Anne Marie Clark, Senior Search Analyst for CAS, discusses how to avoid patent pitfalls as the market for RNAi-derived therapeutics grows.

A critical step in the race to develop treatments for COVID-19 is to gain a clear understanding of how the virus enters our cells. This insight will support development of targeted antiviral treatments focused on blocking that pathway.

To provide a better understanding and comparison of the diagnostic tests available in the fight against COVID-19, CAS has produced a report summarizing the basic principles of molecular and serological assays being used in diagnostic tests for SARS-CoV-2.

To support R&D on COVID-19, CAS has produced a special report to provide an overview of published scientific information with an emphasis on patents in the CAS content collection.

Brazil hosts 15-20% of Earth's biodiversity, yet much remains unexplored. Researchers struggle to search, screen, and compare chemical substances due to disorganized information.

The Journal of Organic Chemistry article "Recent Changes in the Scaffold Diversity of Organic Chemistry As Seen in the CAS Registry" shows the pace of innovation from a structural perspective is accelerating despite the extensive reuse of a relative small number of scaffolds.